Our Mission: Deliver solution-oriented, personalized consulting services that fit your needs and maximize your potential.
Overcome Gaps in Evidence Base with Comprehensive Synthesis Techniques
Our thorough Systematic and Targeted Literature Reviews will provide the relevant research, uncover gaps in knowledge, and inform HEOR strategies.
We can use Bayesian Network Meta-Analyses to combine a wide range of studies and compare many interventions that have not been directly tested against each other at once.
We also have experience with indirect treatment comparison methods such as Matching-Adjusted Indirect Comparison (MAIC).
Let’s Re-Cast the Dogmas of Clinical Trials and RWE Into One
We can identify existing fit-for-purpose RWD with our comprehensive RWD landscape assessment services and design robust External Control Arm (ECA) Studies to enhance your evidence dossier.
We leverage our expertise in Causal Inference, Epidemiology, and Statistics to analyze RWD and single-arm trial data, overcoming biases and drawing reliable conclusions for high-quality RWE.
We provide comprehensive Marginal Structural Modelling capabilities that go beyond typical propensity score matching and weighting methods. Let us help you with causal reasoning to reliably identify and mitigate important confounders.
Enhance the credibility of your RWE by rigorously examining potential biases with Quantitative Bias Assessment.
Our service offerings include Transportability Analysis to examine the external validity of your RWE results.
Maximize Value in Healthcare Choices Between Competing Options
Supplementary to our comparative effectiveness analytical services, we offer Bayesian Cost-Effectiveness Analysis that evaluates your product’s value for money.
Our expertise in preference elicitation and choice modelling, including discrete choice experiments and best-worst scaling surveys, can help you understand patient preferences and tailor new programs and products to maximize patient uptake.
We also provide probabilistic approaches to Budget Impact Analysis to assess financial implications of new programs and interventions.
Our services include Multi-Criteria Decision Analysis (MCDA) to evaluate competing options based on a comprehensive set of decision criteria. We have developed novel Bayesian Multi-Criteria Augmented Decision Analysis (MCADA) methods that offer more comprehensive assessment than existing MCDA methods.
Amplify Patient Voices through Patient and Stakeholder Engagement
We can craft your clinical trial diversity plan to enhance inclusion and meet regulatory requirements.
Our team crafts targeted surveys and questionnaires to capture meaningful insights from patients and other stakeholders.
We possess expertise in qualitative methods to supplement our quantitative services for comprehensive mixed methods approaches.
We specialize in Patient-Reported Outcomes Measurement (PROM) and patient and public engagement to put patients at the center of research.
Optimize Clinical Trial Design from the Ground-Up
We go beyond conventional sample size or power calculations for trial design here at CCS.
We can explore multiple design options with Simulations to choose the most efficient design for your clinical trial. We will work to plan these clinical trials with comprehensive simulations and operational assessments with your stakeholders.
We can utilize data-driven Adaptive Trial Designs and Master Protocols to explore ways to reduce cost and time for your clinical program. With our experience in Basket trials, Umbrella trials, and Platform Trials, we can help design your novel trials for your portfolio
We can leverage our expertise in causal inference and clinical trial methodologies and ensure your trial design and analytical strategies are aligned with the ICH E9 (R1) addendum on Estimands.
Elevate Your Research with Our Team’s Proven Publication Record
Our technical writing services also are complemented by our core services. Whether you need assistance to develop your next study protocol and statistical analysis plan or disseminate your study results, please get in touch with us.
We have a proven track record of publishing peer-reviewed publications in top-tier medical and statistical journals such as JAMA, the Lancet, Statistics in Medicine, and more.
We also have experience preparing HTA, regulatory, public health, and global health guidance documents.
See our Founder’s book on adaptive trial designs and master protocols with the Cambridge University Press that is now available on Amazon.
Premier Education and Training Services on Latest Novel Methods
We have strong roots in academia and a passion for education and teaching. Our Founder / Scientific Lead regularly teaches graduate courses on evidence synthesis and advanced clinical trial methods at McMaster University, the home of Evidence-Based Medicine.
Our education experience spans over 1,000+ students and medical professionals
Please ask us to develop a customized workshop for your organization to ensure you and your colleagues are up to date on the latest clinical trial and evidence synthesis methods.